CMS-1500 Completion Guide

This information is intended to support appropriate claims completion when submitting claims for Ambisome. It is important to confirm payer-specific claims completion requirements and accepted procedure and diagnosis codes before submitting claims. For general billing instructions on the CMS-1500, reference the appropriate Medicare Claims Processing Manual1.

Items 17, 17a, 17b Name of Referring Provider
  • Document the name, UPIN, and NPI of the physician requesting or ordering the services for the patient
  • The NPI of the referring physician is required information in 17B
Item 19 Reserved for Local Use
  • Used to capture additional data to support claims review, including:
  • Concise descriptions of services billed using unlisted procedure codes
  • Applicable modifiers if multiple modifiers are required for a CPT2 or HCPCS code
  • Sometimes used to report prior authorization numbers for private payers and Medicaid plans
Item 21 Diagnosis Codes
  • Report appropriate code(s) based on patient diagnoses and conditions according to medical record documentation
  • Codes should be entered in priority order and to the highest level of specificity
Item 23 Prior Authorization Number
  • Used for various purposes by Medicare
  • Sometimes used to report prior authorization numbers for private payers and Medicaid plans
Item 24 Shaded Portion
  • If required by state for Medicaid drug rebate processes, may be used to capture NDC for Ambisome or other drugs used during patient encounter
  • For Ambisome, enter "N4" followed by 11-digit NDC; for example, to report use of one 50-mg vial of Ambisome: N400469305130
Item 24D Procedures, Services, or Supplies
  • Report appropriate procedure or drug codes based on services provided during patient encounter according to medical record documentation
  • Up to 4 modifiers can be reported following the CPT or HCPCS code
  • Some payers have specific requirements for billing modifiers with drugs that are administered in the home setting via infusion pump. If AmBisome is being administered in this way, confirm modifier billing requirements with the specific payer
  • Include J0289 to report use of Ambisome
  • Some payers may require AmBisome to be reported on the same claim as its administration, if being physician administered, or the infusion pump and related supplies. It is important to confirm claims requirements on a payer-specific basis
Item 24E Diagnosis Pointer
  • Report the number (1,2,3, or 4) corresponding to the diagnosis code from Item 23 that is most relevant to the service or procedure described
Item 24G Days or Units
  • Report the number of times services or procedures being reported were performed during the encounter according to medical record documentation
  • One unit of the code for AmBisome represents 10 mg (partial vial). Report the appropriate number of units based on the amount of AmBisome provided to the patient. To report use of an entire vial, it is appropriate to report 5 units of J0289
Item 24J Rendering Provider ID
  • Document the NPI of the physician rendering services to the patient in the unshaded portion
Item 32a NPI
  • Document the NPI of the service facility
Item 33a NPI
  • Document the NPI of the billing provider or group

1. http://www.cms.hhs.gov/Manuals/IOM/list.asp

2. Current Procedural Terminology (CPT), Professional Edition, 2011. American Medical Association, 2010. All rights reserved. No fee schedules, basic units, relative values, or related listings are included in CPT. The AMA assumes no responsibility for the data contained herein. CPT is a registered trademark of the American Medical Association.

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